Aleksey Gerasyuto
Company: Schrodinger
Job title: Vice President, Drug Discovery
Seminars:
Optimizing Kinase Selectivity & Predicting Resistance Using Physics- Based Modeling 11:00 am
Unlocking kinome-wide selectivity of WEE1 inhibitors through free energy calculations Optimizing selectivity of DLK inhibitors through off-target free energy perturbation (FEP) Predicting clinical resistance with protein-residue-mutation FEPRead more
day: Conference Day One
Panel Discussion: The Kinome Kit – Augmenting Selectivity Profiling Through Assays to Achieve On-Target Specificity 2:00 pm
Evaluating compounds against other kinases to identify potential off-target effects in early development Employing continuous assay systems to access full enzymatic activity over time and monitor various mechanisms of action Uncovering strategies for detecting kinase selectivity to facilitate effective target engagement and improve drug efficacyRead more
day: Conference Day One