Optimizing Kinase Selectivity & Predicting Resistance Using Physics- Based Modeling
Time: 11:00 am
day: Conference Day One
Details:
- Unlocking kinome-wide selectivity of WEE1 inhibitors through free energy calculations
- Optimizing selectivity of DLK inhibitors through off-target free energy perturbation (FEP)
- Predicting clinical resistance with protein-residue-mutation FEP
