Leveraging Selective Inhibition of CDK12/13 Through Degradation of Cyclin K
Time: 4:10 pm
day: Conference Day One
Details:
- Outlining how targeted protein degradation of cyclin K enables discovery of highly selective kinase inhibitors
- Presenting how event-driven pharmacology drives potency and selectivity
- Exploiting the PK/PD disconnect for use to further enhance selectivity window in vivo
