Leveraging Basal Protein-Protein Interactions for Targeted Degradation or Inhibition of Kinases
Time: 1:30 pm
day: Conference Day Two
Details:
- Identifying sub-micromolar, protein-protein interactions between kinases and ligases or chaperones
- Structurally characterizing these interactions using site-directed mutagenesis to prioritize those most suitable for small molecule “glue-ability”
- Translating structural insights into small molecule strategies that promote kinase degradation or inhibition
